Doctors hope for cure in a 2d baby born with HIV - Philly.com

Written By Unknown on Kamis, 06 Maret 2014 | 16.14

Marilynn Marchione, Associated Press
Posted: Thursday, March 6, 2014, 1:08 AM

A second baby born with the AIDS virus appears to be in remission and possibly cured by early treatment - four hours after birth.

Doctors revealed the case Wednesday at an AIDS conference in Boston. The girl was born outside Los Angeles last April, a month after researchers announced the first case from Mississippi. That was a medical first that led doctors worldwide to rethink how fast and hard to treat infants born with HIV, and the California doctors followed that example.

The Mississippi baby is now 31/2 and seems HIV-free despite no treatment for about two years. The Los Angeles baby is still getting AIDS medicines, so her status is not as clear.

A host of sophisticated tests at multiple times suggests the California baby has completely cleared the virus, said Deborah Persaud, a Johns Hopkins University physician who led the testing. The baby's signs are different from what doctors see in patients whose infections are merely suppressed, she said.

"We don't know if the baby is in remission . . . but it looks like that," said Yvonne Bryson, an infectious-disease specialist at Mattel Children's Hospital UCLA who consulted on the case.

Doctors are cautious about suggesting she is cured, but that's the hope.

Most HIV-infected mothers in the United States get AIDS medicines during pregnancy, which greatly cuts the chances they will pass the virus to their babies. The Mississippi baby's mother received no prenatal care and her HIV was discovered during labor. Doctors started the baby on treatment 30 hours after birth, even before tests could determine whether she was infected.

The California baby was born at Miller Children's Hospital Long Beach, and "we knew this mother from a previous pregnancy" and that she was not taking her HIV medicines, said Audra Deveikis, a pediatric infectious-disease specialist at the hospital.

The mother was given AIDS drugs during labor to try to prevent transmission of the virus, and Deveikis started the baby on them a few hours after birth. Tests later confirmed she had been infected but does not appear to be now, nearly a year later.

The baby is continuing treatment, is in foster care "and looking very healthy," Bryson said.


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